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100 to 300 g of fresh leaves are chewed to form a bolus (called a "quid") that is held against the cheek on one side of the mouth while swallowing its juice; a typical "khat session" lasts for 3 to 4 hours. Nicotine and caffeine increase the stimulant effects of khat.
It is a tall evergreen shrub (2.7 to 3.7 m in height) that grows best at high elevations (1,500 to 2,000 m above sea level).
Halbach 1972 Cathine has approximately one-tenth the stimulant activity of d-amphetamine.
The compound has been confused with d,1-norephedrine in the literature; despite identical structural formulas, the 2 compounds differ significantly in pharmacologic properties.
Eisenberg 1987 Cathinone (alpha-aminopropiophenone) has been isolated in variable quantities from fresh khat leaves, with content varying depending on the country of origin.
Patel 2015 Cathinone increases dopamine and norepinephrine through actions on their transporter functions, and is associated with sympathetic activity.
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Its tender twigs and leaves are harvested almost year-round.